Lots of people you know are killjoys. I know many as well and watched this with a couple of such folks. I don't get why some people can't just let their guards down and enjoy these kinds of films from time to time. Not everything has to be fucking poignant, subversive and life-changing. /rant off
I thought it was a hilarious and worth the watch. The main criticism I have is that it had a bit too much shock for shock's sake (raunchy, absurdity, etc.). With all the people involved I know they could have done even better with it.
I was not stoned or drunk and still enjoyed it, but it probably would have been amazing under such conditions. Not one I'll try to watch over and over, but I wouldn't mind seeing it again with the right people.